A new δ-tocotrienolic acid derivative and other constituents from the cones of Cedrus atlantica and their in vitro antimicrobial activity. (June 2017)

• Record Type: Journal Article
• Authors: Maya, Belhadj Mostefa; Abedini, Amin; Gangloff, Sophie C.; Kabouche, Ahmed; Kabouche, Zahia; Voutquenne-Nazabadioko, Laurence
• Is Part Of: Phytochemistry letters. Volume 20(2017:Jun.)
• Page Start: 252
• Page End: 258
• Publication Date: 2017-06
• Subjects: Cedrus atlantica (Endl.) Manetti ex Carrière -- Pinaceae -- Tocotrienolic acid -- Abietane diterpene -- Antimicrobial activity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2017.05.009
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Phytochemical study of the hydromethanolic extract of Cedrus atlantica cones. A δ-tocotrienolic acid derivative and a diacylated flavonol glycoside were new. The hydromethanolic extract was evaluated against 22 micro-organisms. Dehydroabietic acid showed MIC value of 15.1 μg/mL against E. faecalis . Abstract: The phytochemical and antimicrobial properties of the cones of Cedrus atlantica (Endl) Manetti ex Carrière were investigated. Two new compounds (1, 2 ) and nineteen known compounds (3 –21 ) were isolated. Their structures were established by mass spectrometry (HRESIMS), 1D, 2D NMR and by comparison with literature data. Antimicrobial activity of hydromethanolic extract against a panel of 22 bacteria and yeasts showed an interesting antimicrobial activity. All compound purified from this extract were tested against S. aureus by bioautography. MIC values of the most active compounds were determined using a serial dilution technique. The results showed strong antibacterial activity of the abietane diterpenes10, 11, 14, 15, 16 and17 . Dehydroabietic acid (17) was the most potent against Enterococcus faecalis (MIC = 15.1 = μg/mL), a multi-resistant commensal bacterium which can cause the fatal infections in humans.