Arvoredol—An unusual chlorinated and biofilm inhibiting polyketide from a marine Penicillium sp. of the Brazilian coast. (June 2017)

• Record Type: Journal Article
• Authors: Scopel, Marina; Mothes, Beatriz; Lerner, Clea B.; Henriques, Amélia T.; Macedo, Alexandre J.; Abraham, Wolf-Rainer
• Is Part Of: Phytochemistry letters. Volume 20(2017:Jun.)
• Page Start: 73
• Page End: 76
• Publication Date: 2017-06
• Subjects: Marine sponge -- Penicillium sp. -- Biofilm -- Biofilm dispersion -- Polyketide -- Staphylococcus epidermidis; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2017.04.010
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: A Penicillium sp. has been isolated from the marine sponge Axinella corrugata . Arvoredol, a chlorinated polyketide from this isolate is described. Arvoredol inhibits biofilm formation of the pathogen Staphylococcus epidermidis . Abstract: Penicillium sp. F37 has been isolated from the marine sponge Axinella corrugata and shown to be closely related to Penicillium maximae . From the culture of Penicillium sp. F37 arvoredol, a novel chlorinated polyketide with 6, 7-dihydro-4(5H)-benzofuranone moiety has been isolated and characterized by spectroscopic methods Arvoredol prevented biofilm formation of the human pathogen Staphylococcus epidermidis at a concentration of 125 μg mL −1 by 40%. It was also active against colorectal carcinoma HCT116 cells with a MIC of 7.9 μg mL −1 .