A boronate-based ratiometric fluorescent probe for fast selective detection of peroxynitrite. Issue 2 (10th January 2018)

• Record Type: Journal Article
• Authors: Li, Qi; Yang, Zhengyin
• Is Part Of: Tetrahedron letters. Volume 59:Issue 2(2018)
• Page Start: 125
• Page End: 129
• Publication Date: 2018-01-10
• Subjects: Fluorescent probe -- Peroxynitrite -- Ratiometric signals -- Arlybonates; NGNQMOWXYMMDSY-UHFFFAOYSA-N; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2017.12.004
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: A ratiometric fluorescent probe is developed to detect ONOO − concentration. The probe exhibits high sensitivity, selectivity and fast response to ONOO − . Sensing mechanism of the probe for detecting ONOO − is proposed and confirmed. Abstract: Given that peroxynitrite (ONOO − ) is profoundly associated with health and diseases, a new fluorescent probeABT was designed and synthesized for detection of ONOO − .ABT manifested not only ratiometric fluorescence signals simultaneously in response to concentrations of ONOO − (within 10 s), but high selectivity and sensitivity towards ONOO − over other physiological relevant species (detection limit = 26.3 nM). Moreover, ABT worked in a broad pH range with biological relevance. Thus, ABT could be used to quantitative detection of ONOO − concentration and has the potential to efficiently monitor ONOO − in living organisms.