Three new compounds from the roots of Juglans mandshurica Maxim. (June 2017)

• Record Type: Journal Article
• Authors: Li, Jing; Xu, Ping-Sheng; Zou, Zhen-Xing; Zou, Hui; Long, Hong-Ping; Tan, Lei-Hong; Liu, Rui-Huan; Wang, Yi-Kun; Xu, Kang-Ping; Tan, Gui-Shan
• Is Part Of: Phytochemistry letters. Volume 20(2017:Jun.)
• Page Start: 40
• Page End: 44
• Publication Date: 2017-06
• Subjects: Juglans mandshurica Maxim. -- Biflavone glycoside -- Juglbiflavone a -- Triterpenoid -- Cytotoxicity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2017.03.014
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Three new compounds were isolated from the roots of Juglans mandshurica Maxim. Their structures were determined on the basis of extensive spectroscopic analyses. Compound 1 displayed moderate cytotoxicity with IC50 values of 10.08 ± 0.52 μM and 12.44 ± 1.21 μM, respectively. Abstract: A new biflavone glycoside juglbiflavone A (1 ) along with two new lupane-type triterpenes (2-3 ) were identified from the roots of Juglans mandshurica Maxim. Their structures and absolute configurations were elucidated by extensive spectroscopic methods including 1D/2D NMR, HRESIMS and CD. Compound1 is the first example of biflavone glycoside consisted of a flavanol unit and a flavone unit from this genus, which also exhibited moderate cytotoxic activity against SGC-7901 and A549 cell lines in vitro with IC50 values of 10.08 ± 0.52 μM and 12.44 ± 1.21 μM, respectively.