Splenomegaly: Pathophysiological bases and therapeutic options. (January 2018)

• Record Type: Journal Article
• Authors: McKenzie, Campbell V.; Colonne, Chanukya K.; Yeo, Jia Hao; Fraser, Stuart T.
• Is Part Of: International journal of biochemistry & cell biology. Volume 94(2018)
• Page Start: 40
• Page End: 43
• Publication Date: 2018-01
• Subjects: Spleen -- Splenomegaly -- Congestion -- Infiltration -- Work hypertrophy; Biochemistry -- Periodicals; Cytology -- Periodicals; Biochemistry -- Periodicals; Cell Biology -- Periodicals; Biochimie -- Périodiques; Cytologie -- Périodiques; Biochimie; Cytologie; Biochemistry; Cytology; Ressource Internet (Descripteur de forme); Périodique électronique (Descripteur de forme); Periodicals; 572.05
• DOI: 10.1016/j.biocel.2017.11.011
• Languages: English
• ISSNs: 1357-2725

Abstract

Graphical abstract: Abstract: The spleen is the largest immune organ in the human body and is also essential for red blood cell homeostasis and iron recycling. An average human spleen is approximately 10 centimetres in length and weighs 150 g. Pathological conditions can result in the spleen weighing in excess of 2000 g and extending over 30 centrimetres in length. This remarkable property of the spleen to expand is termed splenomegaly. Splenomegaly can occur as a physiological response to stress or as a chronic process that is often detrimental to the wellbeing of the individual. Here, we will discuss the normal function and physiology of the spleen, the pathophysiological bases of splenomegaly and the commonly available therapeutic options. Additionally we will address experimental systems to determine the regulatory mechanisms underlying splenomegaly.