Benefit of particle therapy in re-irradiation of head and neck patients. Results of a multicentric in silico ROCOCO trial. Issue 3 (December 2016)

• Record Type: Journal Article
• Authors: Eekers, Daniëlle B.P.; Roelofs, Erik; Jelen, Urszula; Kirk, Maura; Granzier, Marlies; Ammazzalorso, Filippo; Ahn, Peter H.; Janssens, Geert O.R.J.; Hoebers, Frank J.P.; Friedmann, Tobias; Solberg, Timothy; Walsh, Sean; Troost, Esther G.C.; Kaanders, Johannes H.A.M.; Lambin, Philippe
• Is Part Of: Radiotherapy and oncology. Volume 121:Issue 3(2016:Dec.)
• Page Start: 387
• Page End: 394
• Publication Date: 2016-12
• Subjects: In silico planning study -- Head and neck -- Re-irradiation -- Multicentric trial -- Radiotherapy -- Particle therapy; Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2016.08.020
• Languages: English
• ISSNs: 0167-8140

Abstract

Abstract: Background and Purpose: In this multicentric in silico trial we compared photon, proton, and carbon-ion radiotherapy plans for re-irradiation of patients with squamous cell carcinoma of the head and neck (HNSCC) regarding dose to tumour and doses to surrounding organs at risk (OARs). Material and Methods: Twenty-five HNSCC patients with a second new or recurrent cancer after previous irradiation (70 Gy) were included. Intensity-modulated proton therapy (IMPT) and ion therapy (IMIT) re-irradiation plans to a second subsequent dose of 70 Gy were compared to photon therapy delivered with volumetric modulated arc therapy (VMAT). Results: When comparing IMIT and IMPT to VMAT, the mean dose to all investigated 22 OARs was significantly reduced for IMIT and to 15 out of 22 OARs (68%) using IMPT. The maximum dose to 2% volume ( D 2 ) of the brainstem and spinal cord were significantly reduced using IMPT and IMIT compared to VMAT. The data are available onwww.cancerdata.org . Conclusions: In this ROCOCO in silico trial, a reduction in mean dose to OARs was achieved using particle therapy compared to photons in the re-irradiation of HNSCC. There was a dosimetric benefit favouring carbon-ions above proton therapy. These dose reductions may potentially translate into lower severe complication rates related to the re-irradiation.