Synthesis of 2-alkenyl-3-hydroxyquinolin-4(1H)-ones as promising antimicrobial and fluorescent agents. Issue 2 (11th January 2018)

• Record Type: Journal Article
• Authors: Horák, Radim; Kvapil, Lubomír; Motyka, Kamil; Slaninová, Ludmila; Grepl, Martin; Kořistek, Kamil; Urbášek, Miroslav; Hradil, Pavel; Soural, Miroslav
• Is Part Of: Tetrahedron. Volume 74:Issue 2(2018)
• Page Start: 366
• Page End: 374
• Publication Date: 2018-01-11
• Subjects: Anthranilates -- Quinolinones -- Rearrangement -- Antibacterial -- Fluorescence; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tet.2017.12.010
• Languages: English
• ISSNs: 0040-4020

Abstract

Abstract: 2-Alkenyl-3-hydroxyquinolin-4(1 H )-ones were prepared by the rearrangement of anthranilic acid esters synthesized by two alternative methods. The prepared derivatives were screened for their antimicrobial activities against representative Gram-positive and Gram-negative bacteria, displaying notable minimum inhibitory concentration values against specific strains. The emission spectra of the target quinolines exhibited two well-separated emission bands, and the maximum excitation wavelengths of the selected compounds were detected at relatively high values. Graphical abstract: