Association between polymorphism of SMAD3 gene and risk of sporadic intracranial arterial aneurysms in the Chinese Han population. (January 2018)

• Record Type: Journal Article
• Authors: Liao, Mao-Fan; Gong, Qiu-Wen; Liu, Liang; Xiong, Xiao-Yi; Zhang, Qin; Gong, Chang-Xiong; Yang, Qing-Wu
• Is Part Of: Journal of clinical neuroscience. Volume 47(2018)
• Page Start: 269
• Page End: 272
• Publication Date: 2018-01
• Subjects: Intracranial aneurysm -- SMAD3 -- Polymorphisms -- Genetic susceptibility; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2017.09.006
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: We examined the relationship between SNPs of SMAD3 and intracranial arterial aneurysms. SNPs of SMAD3, rs1065080 was associated with the development of intracranial arterial aneurysms. Large-scale studies are required to confirm the results of this study. Abstract: Intracranial arterial aneurysms (IAAs) are locally abnormal dilations of the cerebral arteries and often result in subarachnoid hemorrhages (SAH). Genetic, molecular and cellular mechanisms of sporadic IAAs forms are poorly understood. In this study, we investigate the association between mothers against decapentaplegic homolog 3 (SMAD3) genotypes and the risk of sporadic intracranial arterial aneurysms among the Chinese Han population. A case-control study was conducted examining 330 IAA patients and 313 controls. There were eight single nucleotide polymorphisms of SMAD3 selected and genotyped using the polymerase chain reaction-ligase detection reaction (PCR-LDR) method. Our results indicated that SMAD3 rs1065080 polymorphism was associated with a risk of IAAs in a codominant model (GA vs GG, OR = 1.433; 95% CI 1.030–1.994; P = 0.032). In summary, we observed that SMAD3 rs1065080 single nucleotide gene polymorphisms were significantly associated with patient susceptibility to IAAs.