Depsidones from Talaromyces stipitatus SK-4, an endophytic fungus of the mangrove plant Acanthus ilicifolius. (June 2017) - Cai, Runlin
Graphical abstract: Highlights: Two new depsidones named talaromyones A and B (1 and2 ) were isolated from Talaromyces stipitatus . New compound's absolute configuration was elucidated by modified Mosher's method. Compound2 showed antibacterial activity against Bacillus subtilis with an MIC value of 12.5 μg/mL. Compounds2, 4 and5 displayed moderate inhibitory activities against α -glucosidase with IC50 values ranging from 48.4 to 99.8 μM. Abstract: An endophytic fungus ( Talaromyces stipitatus SK-4) was isolated from the leaves of a mangrove plant Acanthus ilicifolius . Its crude extract exhibited significant antibacterial activity and was purified to afford two new depsidones, talaromyones A and B (1 and2 ), along with five known depsidone analogs (3–7 ). Their structures, including absolute configuration, were elucidated through extensive spectroscopic data analysis and modified Mosher's method. Compound2 showed antibacterial activity against Bacillus subtilis with an MIC value of 12.5 μg/mL. In the inhibitory assay against α -glucosidase, compounds2, 4 and5 displayed moderate activities with IC50 values ranging from 48.4 to 99.8 μM.