New pyranonaphthazarin and 2-naphthoic acid derivatives from the mangrove endophytic fungus Leptosphaerulina sp. SKS032. (June 2017)

• Record Type: Journal Article
• Authors: Cui, Hui; Liu, Yena; Ding, Meng; Zhang, Zhengrui; Liu, Huiting; Huang, Xishan; She, Zhigang
• Is Part Of: Phytochemistry letters. Volume 20(2017:Jun.)
• Page Start: 214
• Page End: 217
• Publication Date: 2017-06
• Subjects: Pyranonaphthazarin -- 2-naphthoic acid -- Leptosphaerulina sp.; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2017.05.010
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Two new compounds 1 and 2 were isolated and identified for the first time. The structure of 1 was confirmed by 13 C NMR calculations using the GIAO methods. Compound 1 was the fifth example of the pyranonaphthazarin analogues. The structure of 4 was analyzed by X-ray crystallography analysis for the first time. Compounds 1, 2, and 6 exhibited antibacterial activities for Staphylococcus aureus . Abstract: Two new compounds, named leptospyranonaphthazarin A (1 ) and leptosnaphthoic acid A (2 ), together with four known compounds (3–6 ) were isolated from an endophytic fungus Leptosphaerulina sp. SKS032. Their structures were assigned using spectroscopic methods, computational methods, and single-crystal X-ray diffraction analysis. In the antibiotic assay, compounds1, 2, and6 exhibited antibacterial activities against Staphylococcus aureus with minimal inhibitory concentration (MIC) values of 25.0, 50.0, and 50.0 μg/mL, respectively.