Bioactive mexicanolide-type limonoids from the fruits of Trichilia connaroides. (June 2017)

• Record Type: Journal Article
• Authors: Chen, A-Hong; Wen, Qing; Ma, Yan-Lei; Jiang, Zhi-Hua; Liu, Qing-Long; Tang, Jin-Ying; Xu, Wei; Liu, Yan-Ping; Fu, Yan-Hui
• Is Part Of: Phytochemistry letters. Volume 20(2017:Jun.)
• Page Start: 17
• Page End: 21
• Publication Date: 2017-06
• Subjects: Trichilia connaroides -- Mexicanolide-type limonoids -- Trichiconnarones A and B -- Nitric oxide production inhibition; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2017.03.008
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: The constituents of the fruits of Trichilia connaroides were investigated. Two new mexicanolide-type limonoids were isolated from T. connaroides . The anti-inflammatory activities of new compounds 1 and 2 were evaluated in vitro . Compounds 1 and 2 exhibited inhibitory effects with IC50 values comparable to that of hydrocortisone. Abstract: Two new mexicanolide-type limonoids, trichiconnarones A (1 ) and B (2 ), along with six known analogues (3 –8 ), were isolated from the fruits of Trichilia connaroides . The structures of1 and2 were elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons their data with those reported in the literatures. All new compounds were evaluated for their anti-inflammatory activities via examining the inhibitory activity on nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro . Compounds1 and2 exhibited inhibitory effects with IC50 values comparable to that of hydrocortisone.