Chemical constituents from Oncocalyx glabratus and their biological activities. (June 2017)

• Record Type: Journal Article
• Authors: Ahmed, Sarfaraz; Al-Rehaily, Adnan J.; Ahmad, Mohammad S.; Yousaf, Muhammad; Nur-e-Alam, Mohammad; Parvez, Mohammad K.; Al-Dosari, Mohammed S.; Noman, Omar M.; Khan, Shabana I.; Khan, Ikhlas A.
• Is Part Of: Phytochemistry letters. Volume 20(2017:Jun.)
• Page Start: 128
• Page End: 132
• Publication Date: 2017-06
• Subjects: Oncocalyx glabratus -- Flavan gallates -- Anti-HBV activity -- PPAR agonistic activity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2017.04.016
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Seven compounds including three new ones were isolated from the Oncocalyx glabratus . All the compounds are non-cytotoxic on the cell lines used. All the compounds showed mild antiviral activity against hepatitis virus. Two compounds showed dual PPAR agonistic activity. Abstract: Chemical investigation of the aerial parts of Oncocalyx glabratus resulted in the isolation of three new flavan derivatives, 5, 3′, 4′-trihydroxyflavan 7- O -gallate (1 ), 5, 4′-dihydroxyflavan 7-3′- O -digallate (2 ) and 5, 3′-dihydroxyflavan 7-4′- O -digallate (3 ), named oncoglabrinol A, B and C, respectively, together with four known flavonols, (+)-catechin (4 ), (+)-catechin-7- O -gallate (5 ), catechin-7-4′- O -digallate (6A ) and catechin-7-3′- O -digallate (6B ). The structures of the compounds were established by 1D, 2D NMR and ESI-HRMS spectral analyses. The biological activity of the compounds was tested through a series of in vitro assays designed for determining cytotoxicity, antiviral activity against hepatitis B virus, and antidiabetic activity. All compounds were found non-toxic and showed moderate anti-HBV activity. Compounds3 and6 showed dual PPAR agonistic activity while others were not effective.