Heterotypic Ubiquitin Chains: Seeing is Believing. Issue 1 (January 2018)

• Record Type: Journal Article
• Authors: Stolz, Alexandra; Dikic, Ivan
• Is Part Of: Trends in cell biology. Volume 28:Issue 1(2018)
• Page Start: 1
• Page End: 3
• Publication Date: 2018-01
• Subjects: ubiquitin -- heterotypic Ub chain -- K11/K48 branched -- APC/C -- Huntingtin (HTT); Cytology -- Periodicals; Cytology -- Research -- Periodicals; 571.6
• DOI: 10.1016/j.tcb.2017.11.005
• Languages: English
• ISSNs: 0962-8924

Abstract

Abstract : The biological diversity of ubiquitination resides in the multivalent nature of linkage-specific homotypic and heterotypic ubiquitin (Ub) chains. A recent publication by Yau et al. in Cell describes the development of K11/K48-bispecific antibodies and a physiological role for K11/K48 heterotypic chains in regulation of the cell cycle and clearance of aggregated proteins.