Postoperative bradycardia following adenotonsillectomy in children: Does intraoperative administration of dexmedetomidine play a role?. (January 2018)

• Record Type: Journal Article
• Authors: Bush, Benjamin; Tobias, Joseph D.; Lin, Chen; Ruda, James; Jatana, Kris R.; Essig, Garth; Cooper, Jennifer; Tumin, Dmitry; Elmaraghy, Charles A.
• Is Part Of: International journal of pediatric otorhinolaryngology. Volume 104(2018:Jan.)
• Page Start: 210
• Page End: 215
• Publication Date: 2018-01
• Subjects: Dexmedetomidine -- Bradycardia -- Adenotonsillectomy -- Pediatric; ADT adenotonsillectomy -- CI confidence interval -- EA emergence agitation -- ECG electrocardiogram -- HR heart rate -- IQR interquartile range -- OR odds ratio -- OSA obstructive sleep apnea -- PALS Pediatric Advanced Life Support -- SD standard deviation -- SDB sleep-disordered breathing; Otolaryngology -- Periodicals; Pediatrics -- Periodicals; Otolaryngology -- Periodicals; Pediatrics -- Periodicals; Oto-rhino-laryngologie -- Périodiques; Pédiatrie -- Périodiques; 618.9209751
• DOI: 10.1016/j.ijporl.2017.11.025
• Languages: English
• ISSNs: 0165-5876

Abstract

Abstract: Introduction: Dexmedetomidine is a novel pharmacologic agent that has become a frequently used adjunct during care of pediatric patients with obstructive sleep apnea (OSA) undergoing tonsillectomy. While generally safe and effective, dexmedetomidine is associated with adverse effects of hypotension and bradycardia from its central sympatholytic effects. Due to safety concerns, our institution routinely admits patients with OSA for overnight cardiorespiratory monitoring following tonsillectomy. With such monitoring, we have anecdotally noted bradycardia in our patients and sought to investigate whether this was related to the increased use of intra-operative dexmedetomidine. Methods: We retrospectively reviewed records over an 11-month period to compare the incidence of postoperative bradycardia following hospital admission for tonsillectomy in patients who received dexmedetomidine versus those who did not. Results: The study cohort included 921 patients (371 received dexmedetomidine and 550 did not). Bradycardia was asymptomatically noted in 66 patients (7.2%). No patient required medical intervention for the bradycardia or developed clinical symptoms. There was no association of bradycardia with the intra-operative administration of dexmedetomidine (8.9% of patients who received dexmetomidine vs. 9.4% who did not). In multivariable analysis, bradycardia was more common among older patients, with the administration of topical or injected lidocaine, and with specific associated procedures (inferior turbinate coblation with out-fracture or direct laryngoscopy and bronchoscopy). Conclusion: The increased incidence of asymptomatic bradycardia in our post-adenotonsillectomy patients seemed to relate more to increased utilization of postoperative cardiac telemetry, and did not appear associated with the use of dexmedetomidine use intra-operatively.