The influence of tissue antioxidant enzymes and inflammatory cascade in pathology of cystitis: An experimental rat model. (December 2017)

• Record Type: Journal Article
• Authors: Vysakh, A.; Suma, D.; Jayesh, Kuriakose; Jyothis, Mathew; Latha, M.S.
• Is Part Of: Microbial pathogenesis. Volume 113(2017)
• Page Start: 102
• Page End: 106
• Publication Date: 2017-12
• Subjects: Cystitis -- Urinary tract infection -- Antioxidant status -- Inflammation -- Uropathogenic Escherichia coli; Pathogenic microorganisms -- Periodicals; Pathology, Molecular -- Periodicals; Communicable Diseases -- microbiology -- Periodicals; Communicable Diseases -- parasitology -- Periodicals; Micro-organismes pathogènes -- Périodiques; Pathologie moléculaire -- Périodiques; Electronic journals; 616.9041
• DOI: 10.1016/j.micpath.2017.10.035
• Languages: English
• ISSNs: 0882-4010

Abstract

Abstract: We evaluate the role of antioxidant enzyme status and inflammatory cascade in disease progression of cystitis in a rat model. The animals were injected with clinically isolated Uropathogenic Escherichia coli (UPEC) and study the effect of various antioxidant enzymes and inflammatory markers in disease pathology on the 0 th day, 12 h and 7 th day of infection. The antioxidant status of bladder tissue was decreased during the 7 th day of infection. Lipid peroxidation marker MDA was increased on the 7 th day of infection in rats. The histopathology of bladder tissue shows severe inflammation and edema. This study reveals the role of decreased antioxidant status during infection play a vital role in upregulation of inflammation and tissue destruction. Highlights: Biochemical, antioxidant status and histopathological changes associated with disease pathology of cystitis were studied in rat model. Antioxidant markers, oxidative stress markers were changed significantly during 7 th day of infection. Histopathological changes also confirm the severe inflammation associated with cystitis.