Comprehensive mutation analysis of 53 Y-STR markers in father-son pairs. (December 2017)

• Record Type: Journal Article
• Authors: Lang, Min; Ye, Yi; Li, Jienan; Zhang, Youfang; Yuan, Taoxiu; Hou, Yiping
• Is Part Of: Forensic science international. Volume 6(2017)
• Page Start: e57
• Page End: e58
• Publication Date: 2017-12
• Subjects: Mutation rate -- Rapidly mutating Y-STRs (RM Y-STRs) -- AGCU database Y24 -- AGCU Y SUPP -- Y-STRs; Forensic genetics -- Periodicals; Forensic Genetics -- Periodicals; Electronic journals; 614.1
• DOI: 10.1016/j.fsigss.2017.09.004
• Languages: English
• ISSNs: 1875-1768

Abstract

Abstract: The knowledge of mutation rate at Y-STR markers is essential in forensic casework, especially kinship genetic studies. In the present study, one hundred father–son pairs from Chinese Han population were typed with 53 Y STR markers (38 conventional markers and 15 rapidly mutating markers). A total of 28 mutations were detected in 6201 allele transfers. All were one-step mutation. The average estimated mutation rate of 15 rapidly mutating (RM) Y-STRs was 1.05 × 10 −2 (95% CI 5.45 × 10 −3 –1.39 × 10 −2 ), while the average mutation rate of 38 conventional Y-STRs was 1.46 × 10 −3 (95% CI 3.07 × 10 −4 –2.59 × 10 −3 ). In summary, the average mutation rate of 15 RM Y-STRs seemed to be seven times higher than that of 38 conventional Y-STRs.