Orofacial granulomatosis in a 12‐year‐old girl successfully treated with intravenous pulse corticosteroid therapy and chloroquine. Issue 6 (21st September 2017)

• Record Type: Journal Article
• Authors: Lalosevic, Jovan; Gajic‐Veljic, Mirjana; Nikolic, Milos
• Is Part Of: Pediatric dermatology. Volume 34:Issue 6(2017:Nov./Dec.)
• Page Start: e324
• Page End: e327
• Publication Date: 2017-09-21
• Subjects: chloroquine -- Melkersson‐Rosenthal syndrome -- orofacial granulomatosis -- pulse corticosteroid therapy; Pediatric dermatology -- Periodicals; Children -- Diseases -- Periodicals; 618.925
• DOI: 10.1111/pde.13279
• Languages: English
• ISSNs: 0736-8046

Abstract

Abstract: Orofacial granulomatosis, a rare disease in childhood, is characterized by orofacial swelling in the absence of systemic disease. We report the case of a 12‐year‐old girl with asymptomatic erythematous infiltration of her upper lip, cheeks, and chin that had persisted for more than 2 years; biopsy confirmed granuloma formation. Because a large area was affected, intralesional corticosteroids were inappropriate and six cycles of 3‐day intravenous pulse corticosteroid therapy (dexamethasone 1.5mg/kg), repeated once after 4 weeks, was given. Our patient also received oral chloroquine and topical emollients. At the end of the sixth pulse cycle, the infiltration had completely resolved, leaving slight residual erythema.