Hebb-Based Rules of Neural Plasticity: Are They Ubiquitously Important for the Refinement of Synaptic Connections in Development?. (February 2014)
- Record Type:
- Journal Article
- Title:
- Hebb-Based Rules of Neural Plasticity: Are They Ubiquitously Important for the Refinement of Synaptic Connections in Development?. (February 2014)
- Main Title:
- Hebb-Based Rules of Neural Plasticity
- Authors:
- Favero, Morgana
Cangiano, Alberto
Busetto, Giuseppe - Abstract:
- Neuronal death and suppression of functional synaptic inputs are well-known regressive events characterizing PNS and CNS development. In the CNS, participation of activity in synapse elimination has been known ever since the pioneering studies of Hubel and Wiesel, but only recently has a Hebb-based mechanism of spike synchrony versus asynchrony received unequivocal experimental support in the visual system. At the neuromuscular junction (NMJ), where synapse elimination was discovered, the specific function of the "timing of activity" was addressed by only one group of studies and did not receive widespread attention. Here we critically review the latest NMJ investigation advocating an "activity-independent" mechanism for synapse elimination and contrast it with an equally recent study demonstrating a key role for spike timing. Finally, we highlight how the striking similarities between the two mentioned studies on spike timing (visual system and NMJ) establish conclusively its role in the development of the nervous system in general.
- Is Part Of:
- Neuroscientist. Volume 20:Number 1(2014)
- Journal:
- Neuroscientist
- Issue:
- Volume 20:Number 1(2014)
- Issue Display:
- Volume 20, Issue 1 (2014)
- Year:
- 2014
- Volume:
- 20
- Issue:
- 1
- Issue Sort Value:
- 2014-0020-0001-0000
- Page Start:
- 8
- Page End:
- 14
- Publication Date:
- 2014-02
- Subjects:
- synapse elimination -- neuromuscular junction -- spike timing–dependent plasticity -- superior colliculus -- motor neuron
Neurosciences -- Periodicals
Neurology -- Periodicals
Neurobiology -- Periodicals
616.8005 - Journal URLs:
- http://nro.sagepub.com ↗
http://www.sagepub.com ↗
http://firstsearch.oclc.org ↗ - DOI:
- 10.1177/1073858413491148 ↗
- Languages:
- English
- ISSNs:
- 1073-8584
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 5459.xml