Efficient Synthesis of Novel 3‐Phenyl‐5‐thioxo‐3, 4, 5, 6‐tetrahydroimidazo[4, 5‐c]pyrazole‐2(1H)‐carbothioamide Derivatives Using a CeO2–MgO Catalyst and Evaluation of Antimicrobial Activity. (30th June 2017)

• Record Type: Journal Article
• Authors: Moydeen, Meera; Al‐Deyab, Salem S.; Kumar, Radhakrishnan Surendra; Idhayadhulla, Akbar
• Is Part Of: Journal of heterocyclic chemistry. Volume 54:Number 6(2017:Nov.)
• Page Start: 3208
• Page End: 3219
• Publication Date: 2017-06-30
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.2938
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract : Imidazo[4, 5‐ c ]pyrazole derivatives (3a–f, 4a–f, and5a–f ) were efficiently synthesized by one‐pot three‐component reactions using CeO2 –MgO as the catalyst. The synthesized compounds were characterized by IR, 1 H NMR, 13 C NMR, and mass spectroscopic analyses. The in vitro antimicrobial activity of the synthesized compounds against various bacterial and fungal strains was screened. Compound3b was highly active [minimum inhibitory concentration (MIC): 0.5 μg/mL] against Gram‐positive Staphylococcus aureus, and compounds3b, 3f, 4d, and4e were highly active (MIC: 0.5, 2, 2, and 0.5 μg/mL, respectively) against Gram‐negative Pseudomonas aeruginosa and Klebsiella pneumoniae, relative to standard ciprofloxacin in the antibacterial activity screening. Compounds3b and4f were highly active (MIC: 4 and 0.5 μg/mL, respectively) against Aspergillus fumigatus and Microsporum audouinii in the antifungal activity screening compared with the clotrimazole standard. Abstract :