Different iron deposition patterns in early- and middle-late-onset Parkinson's disease. (November 2017)

• Record Type: Journal Article
• Authors: Xuan, Min; Guan, Xiaojun; Gu, Quanquan; Shen, Zhujing; Yu, Xinfeng; Qiu, Tiantian; Luo, Xiao; Song, Ruirui; Jiaerken, Yerfan; Xu, Xiaojun; Huang, Peiyu; Luo, Wei; Zhang, Minming
• Is Part Of: Parkinsonism & related disorders. Volume 44(2017)
• Page Start: 23
• Page End: 27
• Publication Date: 2017-11
• Subjects: Parkinson's disease -- Early-onset Parkinson's disease -- Middle-late-onset Parkinson's disease -- Iron -- Quantitative susceptibility mapping; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2017.08.013
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Background: Iron deposition may contribute to the clinical symptoms in Parkinson's disease (PD). With partial different clinical manifestations, the iron deposition patterns between patients with early-onset Parkinson's disease (EOPD) and middle-late-onset Parkinson's disease (M-LOPD) are still unclear. This study was designed to investigate the patterns of iron deposition and their clinical relevance in EOPD and M-LOPD patients, using quantitative susceptibility mapping technique. Materials and methods: Thirty-five EOPD patients and 24 matched young controls, 33 M-LOPD patients and 22 matched older controls were recruited in the study. The iron content in the deep grey matter nuclei in the basal ganglia and midbrain were measured, and compared between patients and their corresponding controls. The correlations of regional iron content and clinical features were explored in patient groups. Results: Both M-LOPD and EOPD patients showed increased iron content in the substantia nigra (SN) pars compacta and SN pars reticulata. Increased iron content in the putamen was only observed in M-LOPD patients. The relationship between the increased iron content and disease severity (H&Y stages, UPDRS II scores and UPDRS III scores) was observed in M-LOPD patients, but not in EOPD patients. Conclusion: Our study suggested that the iron deposition pattern was greatly influenced by the age of PD onset, which increases our understanding of the different pathological underpinnings of EOPD and M-LOPD patients. Highlights: There are different onset-age-related patterns of iron deposition between M-LOPD and EOPD patients. Increased iron content was correlated to the disease severity in M-LOPD but not in EOPD patients. The increased putaminal iron content was only observed in M-LOPD patients.