Association of multiple genetic variants with chronic obstructive pulmonary disease susceptibility in Hainan region. (12th November 2015)

• Record Type: Journal Article
• Authors: Ding, Yipeng; Niu, Huan; Zhou, Long; Zhou, Wenjing; Chen, Jiannan; Xie, Shiliang; Geng, Tingting; Ouyang, Yanhong; He, Ping; Sun, Pei; Feng, Tian; Jin, Tianbo
• Is Part Of: Clinical respiratory journal. Volume 11:Number 6(2017)
• Page Start: 727
• Page End: 732
• Publication Date: 2015-11-12
• Subjects: case‐control study – chronic obstructive pulmonary disease – genetic association – Hainan region – single nucleotide polymorphisms; Respiratory organs -- Diseases -- Periodicals; Respiratory organs -- Periodicals; 616.24
• DOI: 10.1111/crj.12407
• Languages: English
• ISSNs: 1752-6981

Abstract

Abstract: Background and Aims: Recent genome‐wide association studies have shown associations between variants in loci (4q28.1, 6p21.32, 6p21.1, 6q16.1, 10q22.1 and 10q22.3) and chronic obstructive pulmonary disease (COPD) or smoking behaviors. The objective of this study was to look for associations between 16 single nucleotide polymorphisms (SNP) at these six loci and COPD susceptibility in Hainan region. Methods: A case‐control cohort was composed of 200 COPD cases and 401 controls that were genotyped and analyzed statistically. Odds ratios (OR) and 95% confidence intervals (CIs) were computed by chi‐square (χ 2 ) test and genetic models by unconditional logistic regression. Results: After Hardy–Weinberg equilibrium (HWE) P value screening, we excluded the SNP rs12220777 with P < 0.001. By χ 2 test only rs9296092 which located on 6p21.32 was provided the strongest evidence of an increasing risk of COPD with an OR of 3.28 (95% CI = 1.03 – 2.32; P = 0.003) between cases and controls. By genetic models analysis, we not only found rs9296092 increased COPD risk, but also found in the over‐dominant model the genotype 'C/T' (OR = 0.55; 95% CI = 0.33 – 0.93; P = 0.023) of rs950063 was proved to be associated with decreased COPD risk. Conclusions: This study is the first to provide evidence of importance of rs9296092 and rs950063 for risk of COPD in Hainan Province. Further studies are needed to characterize the functional sequences that cause COPD.