Could soluble urokinase plasminogen receptor (suPAR) be used as a diagnostic biomarker for ventilator‐associated pneumonia?. (9th February 2016)

• Record Type: Journal Article
• Authors: Sunnetcioglu, Aysel; Sunnetcioglu, Mahmut; Adıyaman, Fırat; Binici, Irfan; Soyoral, Lokman
• Is Part Of: Clinical respiratory journal. Volume 11:Number 6(2017)
• Page Start: 925
• Page End: 930
• Publication Date: 2016-02-09
• Subjects: C reactive protein -- leukocyte count – ventilator‐associated pneumonia -- soluble urine plasminogen kinase activator; Respiratory organs -- Diseases -- Periodicals; Respiratory organs -- Periodicals; 616.24
• DOI: 10.1111/crj.12438
• Languages: English
• ISSNs: 1752-6981

Abstract

Abstract: Background: Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker that is increasingly used for evaluation of systemic inflammation. This study was performed to investigate whether suPAR may possess a diagnostic value in patients with ventilator‐associated pneumonia (VAP). Methods: This clinical study was performed in the anesthesia intensive care units (ICUs) of our university. In addition to descriptive data, WBC, serum levels of C‐reactive protein (CRP) and suPAR prior to and after development of VAP were noted and compared in 31 patients (22 men, 9 women) diagnosed with VAP (Study Group) and 19 patients without VAP (Control Group) in ICU (14 men, 5 women). Results: The suPAR ( P = 0.023), CRP ( P = 0.037), WBCs ( P = 0.024) in patients with VAP were significantly higher than patients without VAP. There was no remarkable difference in terms of WBCs ( P = 0.052) and suPAR levels ( P = 0.616) between groups on the first day of connection to mechanical ventilator. The suPAR and CRP levels in patients with VAP were significantly higher than prior to development of VAP ( P = 0.001 for both). Area under curve value after diagnosis of pneumonia was found 0.248 ( P = 0.002). Conclusion: To conclude, our results suggest that suPAR can be a useful diagnostic biomarker in patients with VAP. However, clinical trials on larger series are warranted to explore the clinical significance more accurately.