Red Blood Cell Distribution Width Is Associated With All‐Cause and Cardiovascular Mortality in Hemodialysis Patients. Issue 6 (29th September 2017)

• Record Type: Journal Article
• Authors: Fukasawa, Hirotaka; Ishibuchi, Kento; Kaneko, Mai; Niwa, Hiroki; Yasuda, Hideo; Kumagai, Hiromichi; Furuya, Ryuichi
• Is Part Of: Therapeutic apheresis and dialysis. Volume 21:Issue 6(2017)
• Page Start: 565
• Page End: 571
• Publication Date: 2017-09-29
• Subjects: Cardiovascular disease -- Hemodialysis -- Mortality -- Red blood cell distribution width; Hemapheresis -- Periodicals; Dialysis -- Periodicals; Blood Component Removal -- Periodicals; Renal Dialysis -- Periodicals; Hémaphérèse -- Périodiques; Dialyse -- Périodiques; Sang -- Collecte et conservation -- Périodiques; 616
• DOI: 10.1111/1744-9987.12579
• Languages: English
• ISSNs: 1744-9979

Abstract

Abstract: Red blood cell distribution width (RDW) is an index of red blood cell variability that is usually used to differentiate the cause of anemia. However, clinical evidence for the relationship between RDW and mortality in hemodialysis patients is still lacking. We performed a single center, prospective longitudinal study. During more than 5 years of follow‐up in 80 patients undergoing maintenance hemodialysis, 34 patients (42.5%) died. In the Kaplan–Meier curve analyses, higher RDW levels (≥ 14.9%) were significantly associated with all‐cause and cardiovascular mortality (log‐rank test, P < 0.05, each). In multivariate Cox proportional hazard models, each 1.0% increase in RDW value predicted an estimated 25% higher risk of mortality ( P < 0.05) and a 40% higher risk of cardiovascular mortality ( P < 0.05). In conclusion, higher RDW value was a significant predictor for all‐cause and cardiovascular mortality in patients undergoing maintenance hemodialysis.