Early-Onset Acquired Myasthenia Gravis Secondary to Anti–Muscle-Specific Kinase Autoantibodies. (January 2014)

• Record Type: Journal Article
• Authors: Yilmaz, Sanem; Gokben, Sarenur; Serdaroglu, Gul; Akcay, Ayfer
• Is Part Of: Journal of child neurology. Volume 29:Number 1(2014:Jan.)
• Page Start: 108
• Page End: 110
• Publication Date: 2014-01
• Subjects: autoimmune myasthenia gravis -- muscle-specific kinase antibody; Nervous system -- Diseases -- Periodicals; 618.928
• DOI: 10.1177/0883073812467689
• Languages: English
• ISSNs: 0883-0738

Abstract

Autoimmune myasthenia gravis is rarely seen during infancy. Similar to adults, 85% to 90% of generalized pediatric myasthenia gravis cases have acetylcholine receptor antibodies. Approximately 30% of the remaining cases have antibodies against muscle-specific kinase. Information on the clinical course, treatment alternatives, and prognosis of pediatric muscle-specific kinase antibody–positive myasthenia gravis is limited because of the small number of cases. Here, we present a 14-month-old girl with muscle-specific kinase antibody–positive myasthenia gravis as one of the youngest patients described so far in the literature.