Effect of gravity on subject-specific human lung deformation. Issue 1 (2nd January 2018)

• Record Type: Journal Article
• Authors: Seyfi Noferest, Behnaz; Santhanam, Anand P.; Ilegbusi, Olusegun J.
• Is Part Of: Mathematical and computer modelling of dynamical systems. Volume 24:Issue 1(2018)
• Page Start: 87
• Page End: 101
• Publication Date: 2018-01-02
• Subjects: Human lung deformation -- gravity -- biomechanical model -- finite element analysis; Engineering -- Mathematical models -- Periodicals; Computer simulation -- Periodicals; 515.39
• DOI: 10.1080/13873954.2017.1382537
• Languages: English
• ISSNs: 1387-3954

Abstract

ABSTRACT: A biomechanical model of human lung is developed and used to investigate the effect of gravity on lung deformation. The lung is assumed to behave as a poro-elastic medium with spatially dependent elastic property. Finite element analysis is performed on a three-dimensional (3D) lung geometry reconstructed from a four-dimensional Computed Tomography (4DCT) scan dataset of human patient. The spatially dependent Young's modulus (YM) values are estimated using inverse analysis from a linear elastic deformation model. The predicted deformation of selected landmarks is monitored with and without gravity, and compared with data obtained from 4DCT registration. The results show that gravity indeed significantly affects the magnitude and distribution of lung deformation with the maximum displacement enhanced by 54% in the direction of gravity, for the conditions investigated. In summary, the accuracy of predicted deformation is improved through incorporation of gravity in the biomechanical model of lung.