Maternal serum autotaxin levels in early- and late-onset preeclampsia. (2nd October 2017)

• Record Type: Journal Article
• Authors: Erenel, Hakan; Yilmaz, Nevin; Cift, Tayfur; Bulut, Berk; Sozen, Isik; Aslan Cetin, Berna; Gezer, Altay; Ekmekci, Hakan; Kaya, Baris; Tuten, Abdullah
• Is Part Of: Hypertension in pregnancy. Volume 36:Number 4(2017)
• Page Start: 310
• Page End: 314
• Publication Date: 2017-10-02
• Subjects: Preeclampsia -- autotaxin -- pregnancy -- early-onset preeclampsia -- late-onset preeclampsia; Hypertension in pregnancy -- Periodicals; Pregnancy -- Complications -- Periodicals; 618.3261
• DOI: 10.1080/10641955.2017.1388389
• Languages: English
• ISSNs: 1064-1955

Abstract

ABSTRACT: Purpose : We aimed to compare the serum autotaxin levels in early- and late- preeclamptic and healthy pregnant patients at a university hospital. Methods : A total of 55 singleton preeclamptic women who delivered at Cerrahpasa Medical Faculty were included in the study. The patients were subdivided into two groups: early-onset preeclampsia ( n = 31) and late-onset preeclampsia ( n = 24). Demographic and clinical data were compared between early-onset and late-onset preeclamptic patients. The control group was composed of 32 healthy pregnant patients. Results : The mean autotaxin levels were 1.16 ± 0.97 and 0.7 ± 0.35 ng/ml in the early- and late-onset preeclampsia groups, respectively. Autotaxin levels were significantly higher in early-onset preeclampsia group compared with late-onset preeclampsia group. Autotaxin levels were found to be significantly higher in preeclamptic patients compared with control group. Serum autotaxin levels showed a significant positive correlation with maternal systolic, diastolic blood pressures and uric acid levels. Conclusion : Autotaxin might be a promising marker for detecting early-onset preeclampsia. However, further studies are necessary to confirm this hypothesis.