Facile expeditious one-pot synthesis and antifungal evaluation of disubstituted 1, 2, 3-triazole with two amide linkages. Issue 23 (2nd December 2017)

• Record Type: Journal Article
• Authors: Kaushik, C. P.; Luxmi, Raj
• Is Part Of: Synthetic communications. Volume 47:Issue 23(2017)
• Page Start: 2225
• Page End: 2231
• Publication Date: 2017-12-02
• Subjects: 1, 3-Dipolar cycloaddition -- 1, 4-disubstituted 1, 2, 3-triazoles -- antifungal activity -- synthesis; Organic compounds -- Synthesis -- Periodicals; Chemistry, Organic; Synthesis; 547.205
• DOI: 10.1080/00397911.2017.1369124
• Languages: English
• ISSNs: 0039-7911

Abstract

ABSTRACT: A library of twenty five amide linked 1, 4-disubstituted 1, 2, 3-triazoles have been prepared through a facile expeditious synthetic protocol involving Cu(I) mediated cyclization of N -(2-methylbut-3-yn-2-yl)aromatic amides and in situ generated 2-azido- N -substituted propanamides. Structures of newly synthesized compounds (5a –5y ) were confirmed by analytical techniques, such as FTIR, 1 H NMR, 13 C NMR, and HRMS. In vitro antifungal activity was also examined against two fungal strains Candida albicans and Aspergillus niger by serial dilution method. The compounds5 m and5w exhibited appreciable potent activity. GRAPHICAL ABSTRACT: