Compounds with inhibitory activity on peristalsis from the seeds of Holarrhena antidysenterica. Issue 4 (16th February 2018)

• Record Type: Journal Article
• Authors: Xie, Hai-Hua; Su, Jian; Ge, Xiao-Lei; Dong, Ting-Ting; Li, Xin; Wen, Hui-Min; Sun, Bo-Hang
• Is Part Of: Natural product research. Volume 32:Issue 4(2018)
• Page Start: 418
• Page End: 424
• Publication Date: 2018-02-16
• Subjects: Holarrhena antidysenterica -- chemical constituents -- isolation -- identification -- peristalsis inhibitory; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1315574
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Eight compounds were isolated from the seeds of Holarrhena antidysenterica Wall.ex A.DC. On the basis of physico-chemical properties and spectroscopic data, holarrhenanan (1 ) was identified as a new compound, compounds2 –3 were isolated from H. antidysenterica for the first time, and five known compounds were also obtained. Inhibitory effects of some compounds and extracts to the intestinal peristalsis were evaluated. Results showed that the extracts and compounds4, 6 exhibited remarkable inhibitory effects with tension inhibition rate of 32.77, 32.77% and amplitude inhibition rate of 59.51, 55.98%, respectively on the vitro rabbit intestinal peristalsis. Abstract :