LC-ESI-MS/MS profiling of phenolics in the leaves of Eleutherococcus senticosus cultivated in the West Europe and anti-hyaluronidase and anti-acetylcholinestarase activities. Issue 4 (16th February 2018)

• Record Type: Journal Article
• Authors: Kuźniewski, Rafał; Załuski, Daniel; Olech, Marta; Banaszczak, Piotr; Nowak, Renata
• Is Part Of: Natural product research. Volume 32:Issue 4(2018)
• Page Start: 448
• Page End: 452
• Publication Date: 2018-02-16
• Subjects: Eleutherococcus -- LC-ESI-MS/MS -- phenolic acids -- flavonoids -- Hyal -- AChE; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1308369
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Neither secondary metabolites of the spring leaves nor the autumn leaves of Eleutherococcus senticosus species cultivated in Poland, or the bioactivity are known. The richest in polyphenols was the autumn leaves (171.1 mg/g DE), while in flavonoids the spring leaves (107.9 mg/g DE). Using LC-ESI-MS/MS, protocatechuic acid has been identified as the most abundant compound in the spring and autumn leaves (200 and 70 μg/g DE, respectively). Amongst flavonoids, naringenin 7- O -glucoside occurred in the largest amount (20 and 10 mg/g DE in the spring and autumn leaves, respectively). The autumn leaves inhibited Hyal the strongest (74.3%), comparing to the spring leaves (33%). A weak inhibition was found towards AChE (0.64 and 5.8% for the autumn and spring leaves, respectively). To our best knowledge, no information was available on the phytochemical composition and activity of the leaves of E. senticosus cultivated in Poland. Abstract :