Advances in asymmetric oxidative kinetic resolution of racemic secondary alcohols catalyzed by chiral Mn(III) salen complexes. Issue 12 (29th September 2017)

• Record Type: Journal Article
• Authors: Ahmad, Irshad; Shagufta, ; AlMallah, Abdul Rahman
• Is Part Of: Chirality. Volume 29:Issue 12(2017)
• Page Start: 798
• Page End: 810
• Publication Date: 2017-09-29
• Subjects: chiral catalysts -- Mn(III) salen complex -- oxidative kinetic resolution -- racemic secondary alcohols; Chirality -- Periodicals; Pharmaceutical chemistry -- Periodicals; 541.22
• DOI: 10.1002/chir.22768
• Languages: English
• ISSNs: 0899-0042

Abstract

Abstract: Enantiomerically pure secondary alcohols are essential compounds in organic synthesis and are used as chiral auxiliaries and synthetic intermediates in the pharmaceutical, agrochemical, and fine chemical industries. One of the attractive and practical approaches to achieving optically pure secondary alcohols is oxidative kinetic resolution of racemic secondary alcohols using chiral Mn(III) salen complexes. In the last decade, several chiral Mn(III) salen complexes have been reported with excellent enantioselectivity and activity in the homogeneous and heterogeneous catalysis of the oxidative kinetic resolution of racemic secondary alcohols. This review article is an overview of the literature on the recent development of chiral Mn(III) salen complexes for oxidative kinetic resolution of racemic secondary alcohols. The catalytic activity of monomeric, dimeric, macrocyclic, polymeric, and silica/resin supported chiral Mn(III) salen complexes is discussed in detail. Abstract :