Copper‐Catalysed Decarboxylative Trifluoromethylation of β‐Ketoacids. Issue 11 (12th July 2017)

• Record Type: Journal Article
• Authors: Xu, Xiaolan; Chen, Huanhuan; He, Jianbo; Xu, Huajian
• Is Part Of: Chinese journal of chemistry. Volume 35:Issue 11(2017)
• Page Start: 1665
• Page End: 1668
• Publication Date: 2017-07-12
• Subjects: β‐ketoacids -- decarboxylative -- trifluoromethylation -- α‐trifluoromethyl ketones; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/cjoc.201700271
• Languages: English
• ISSNs: 1001-604X

Abstract

Abstract : An efficient method for Cu‐catalyzed decarboxylative trifluoromethylation of β ‐ketoacids to achieve α ‐trifluoromethyl ketones was developed. A wide variety of synthetically useful α ‐trifluoromethyl ketones were obtained in modest to good yields under mild reaction conditions. The present method also exhibits good functional‐group compatibility. Abstract : An efficient method for Cu‐catalyzed decarboxylative trifluoromethylation of β ‐ketoacids to achieve α ‐trifluoromethyl ketones was developed. A wide variety of synthetically useful α ‐trifluoromethyl ketones were obtained in modest to good yields under mild reaction conditions. The present method also exhibits good functional‐group compatibility.