Cellular identity crisis: Antiandrogen resistance by lineage plasticity. Issue 11 (2nd November 2017)
- Record Type:
- Journal Article
- Title:
- Cellular identity crisis: Antiandrogen resistance by lineage plasticity. Issue 11 (2nd November 2017)
- Main Title:
- Cellular identity crisis: Antiandrogen resistance by lineage plasticity
- Authors:
- Tuerff, Daniel
Sissung, Tristan
Figg, William D. - Abstract:
- ABSTRACT: A recent publication in Science demonstrates the ability of prostate cancer cells to switch lineages from one that is dependent on androgen signaling to a cell type that is not. Known as lineage plasticity, this phenomenon is driven by the transcription factor SOX2 in RB1 and TP53-deficient prostate cancer. SOX2 is a potential prognostic marker and therapeutic target in castration resistant prostate cancer.
- Is Part Of:
- Cancer biology & therapy. Volume 18:Issue 11(2017)
- Journal:
- Cancer biology & therapy
- Issue:
- Volume 18:Issue 11(2017)
- Issue Display:
- Volume 18, Issue 11 (2017)
- Year:
- 2017
- Volume:
- 18
- Issue:
- 11
- Issue Sort Value:
- 2017-0018-0011-0000
- Page Start:
- 841
- Page End:
- 842
- Publication Date:
- 2017-11-02
- Subjects:
- Lineage plasticity -- prostate cancer -- CRPC -- antiandrogen -- SOX2 -- TP53 -- RB1
616.99406 - Journal URLs:
- http://www.tandfonline.com/ ↗
- DOI:
- 10.1080/15384047.2017.1323599 ↗
- Languages:
- English
- ISSNs:
- 1538-4047
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3046.456700
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 5449.xml