NMR-based assignment of isoleucine vs. allo-isoleucine stereochemistry. Issue 44 (1st November 2017) - Anderson, Zoe J.
Abstract : A simple 1 H and 13 C NMR spectrometric analysis is demonstrated that permits differentiation of isoleucine and allo -isoleucine residues by inspection of the chemical shift and coupling constants of the signals associated with the proton and carbon at the α-stereocentre. Abstract : A simple 1 H and 13 C NMR spectrometric analysis is demonstrated that permits differentiation of isoleucine and allo -isoleucine residues by inspection of the chemical shift and coupling constants of the signals associated with the proton and carbon at the α-stereocentre. This is applied to the estimation of epimerisation during metal-free N -arylation and peptide coupling reactions.