Topographical and chemical effects of electrochemically assisted deposited hydroxyapatite coatings on osteoblast-like cells. (February 2014)

• Record Type: Journal Article
• Authors: Pegg, Elise C; Matboli, Faisal; Marriott, Tim; Khan, Imran; Scotchford, Colin A
• Is Part Of: Journal of biomaterials applications. Volume 28:Number 6(2014:Feb.)
• Page Start: 946
• Page End: 953
• Publication Date: 2014-02
• Subjects: Fixation -- hydroxyapatite -- bone -- topography -- chemistry -- surface; Biomedical engineering -- Periodicals; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1177/0885328213487410
• Languages: English
• ISSNs: 0885-3282

Abstract

A recently commercialised hydroxyapatite electrochemically assisted chemical deposition technique (BoneMaster) has been shown to induce increased bone apposition; whether this response is caused by the surface topography or chemistry is unknown. An in-vitro examination using human osteoblast-like cells was performed on a series of BoneMaster-coated surfaces. The chemistry was separated from the topography using a thin gold coating; Thermanox coverslips were used as a control. BoneMaster surfaces showed significantly greater alkaline phosphatase activity and osteocalcin production compared with controls; however, no difference was found between the gold-coated and uncoated BoneMaster samples, indicating topography is the main contributing factor.