Enhanced antioxidant activity, antibacterial activity and hypoglycemic effect of luteolin by complexation with manganese(ii) and its inhibition kinetics on xanthine oxidase. Issue 84 (22nd November 2017)

• Record Type: Journal Article
• Authors: Dong, Hao; Yang, Xiaocui; He, Jiapeng; Cai, Sheng; Xiao, Kaijun; Zhu, Liang
• Is Part Of: RSC advances. Volume 7:Issue 84(2017)
• Page Start: 53385
• Page End: 53395
• Publication Date: 2017-11-22
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra11036g
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A coordination compound with enhanced biological activities was synthesized with luteolin and manganese(ii ) cation. The inhibition effect assay found that the complex reversibly inhibited xanthine oxidase in a competitive manner. Abstract : The present study aims to improve the biological activities of luteolin by complexation with manganese(ii ). UV-visible spectroscopy, infrared spectroscopy, thermogravimetric analysis and elemental analysis were adopted to assess the relevant interaction of luteolin and manganese(ii ) ions and the chelation sites. The antioxidant activity, hypoglycemic effect and antimicrobial activity of luteolin–manganese(ii ) complex with respect to its parent luteolin and the inhibition effect of which on xanthine oxidase were investigated and compared. The spectroscopic data indicated that luteolin reacts with manganese(ii ) cations through the chelation sites of 5-hydroxy and 4-carbonyl in two luteolin molecules. Antioxidant and antibacterial activity were enhanced after the complexation of manganese(ii ) cations with luteolin. An inhibition effect assay found that luteolin and luteolin–manganese(ii ) complex reversibly inhibited xanthine oxidase in a competitive manner. Luteolin–manganese(ii ) complex had a more remarkable hypoglycemic effect than luteolin by increasing the glucose consumption in liver tissue.