Cancer nanomedicine: from PDGF targeted drug delivery. Issue 11 (16th October 2017)

• Record Type: Journal Article
• Authors: Rejeeth, Chandrababu; Vivek, Raju; NipunBabu, Varukattu; Sharma, Alok; Ding, Xianting; Qian, Kun
• Is Part Of: MedChemComm. Volume 8:Issue 11(2017)
• Page Start: 2055
• Page End: 2059
• Publication Date: 2017-10-16
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19
• DOI: 10.1039/c7md00391a
• Languages: English
• ISSNs: 2040-2503

Abstract

Abstract : An innovative approach for the distinctively efficient action of smart targeted drug delivery to a specific cell type is obtained through the modification of the surface of nanoparticles. Abstract : An innovative approach for the distinctively efficient action of smart targeted drug delivery to a specific cell type is obtained through the modification of the surface of nanoparticles. Specifically, the work identifies a cell surface receptor targeting drug delivery nanosystem based on mesoporous silica loaded with the anticancer drug cisplatin ( cis -DDP) and poly-acrylic acid (PAA). A specific target is the PDGF receptors expressed in cervical cancer cells, thus making the PAA functionalized nanocomposite a suitable and promising nano-medicine for the targeting of PDGF-overexpressing cancers in the near future.