Pattern of hematological malignancies in adolescents and young adults in Bangladesh. (December 2017)

• Record Type: Journal Article
• Authors: Hasan, Md. Mahbub; Raheem, Enayetur; Sultana, Tanvira Afroze; Hossain, Mohammad Sorowar
• Is Part Of: Cancer epidemiology. Volume 51(2017:Dec.)
• Page Start: 109
• Page End: 112
• Publication Date: 2017-12
• Subjects: Adolescents and young adults -- Leukemia -- Lymphoma -- Hematological malignancy -- Bangladesh; Cancer -- Epidemiology -- Periodicals; Cancer -- Prevention -- Periodicals; Cancer -- Diagnosis -- Periodicals; Carcinogenesis -- Periodicals; 616.994005
• DOI: 10.1016/j.canep.2017.11.001
• Languages: English
• ISSNs: 1877-7821

Abstract

Highlights: A large of number (n=2144) of hematological malignancy cases among adolescents and young adults (AYAs) in Bangladesh has been analyzed. This is the first report on any cancer type particularly focusing on AYA age group from Bangladesh. Acute myeloid leukemia (AML) was the most frequent HM (35.1%) among AYAs in Bangladesh. Abstract: Introduction: The adolescent and young adult (AYA) age group (15–39 years) bears distinct characteristics in terms of cancer biology, long-term health and treatment-related complications and psychosocial aspects. The overall scenario of cancer including hematological malignancies (HMs) is largely unknown in Bangladesh, where a significant proportion of people (44% of total population) belong to AYA age group. This study aims to describe the patterns of HM among AYA in the context of Bangladesh Methods: Two previously published datasets (on hematological malignancies and childhood and adolescent cancer) were merged to construct a comprehensive dataset focusing exclusively on HMs in AYA age group. Univariate descriptive statistics were calculated and bivariate association were tested using Pearson's Chi-square test. Results: A total of 2144 diagnosed HM related cases over a period of 2007–2014 were analyzed. Acute myeloid leukemia (AML) was the most frequent HM (35.1%) in AYAs, which was followed by acute lymphoblastic leukemia (ALL) and chronic myeloid leukemia (CML) constituting 22.7% and 20.8%, respectively. Among lymphomas, Non-Hodgkin lymphoma (NHL) constituted 13.9% of all HMs while 4.6% was for Hodgkin's lymphoma (HL). Conclusion: This is the first attempt to provide a glimpse on the pattern and distribution of HMs among AYA in Bangladesh. Future studies are essential to get a better insight on the epidemiology, biology, potential risk factors and treatment outcomes for the AYA age group.