Changes in matrix metalloproteinase-9 levels during progression of atrial fibrillation. (February 2014)

• Record Type: Journal Article
• Authors: Li, Mingjiang; Yang, Guokang; Xie, Bin; Babu, Kamesh; Huang, Congxin
• Is Part Of: Journal of international medical research. Volume 42:Number 1(2014:Feb.)
• Page Start: 224
• Page End: 230
• Publication Date: 2014-02
• Subjects: Atrial fibrillation -- concentration -- disease progression -- extracellular matrix -- matrix metalloproteinase-9 -- pathological mechanism; Medicine -- Periodicals; Pharmacology -- Periodicals; 610.5
• DOI: 10.1177/0300060513488514
• Languages: English
• ISSNs: 0300-0605

Abstract

Objectives: To observe levels of matrix metalloproteinase (MMP)-9 and evaluate their significance in various stages of idiopathic atrial fibrillation (AF). Methods: Patients with idiopathic AF were recruited into this prospective study and classified into one of three groups according to stage of disease progression: paroxysmal AF; persistent AF; permanent AF. Healthy individuals were enrolled as control subjects. Serum levels of MMP-9 in all four groups were determined using a double-antibody sandwich enzyme-linked immunosorbent assay. Results: Each AF group included 25 patients; 40 healthy individuals were included as controls. MMP-9 levels in the three AF groups were significantly higher than in the control group: 168.72 ± 25.970, 201.36 ± 31.26 and 253.20 ± 22.99 ng/ml for the paroxysmal, persistent and permanent AF groups respectively, versus 76.80 ± 14.90 ng/ml for the control group. MMP-9 levels increased with idiopathic AF disease progression ( P < 0.05). Conclusions: An elevated MMP-9 level appears to be associated with a diagnosis of AF. MMP-9 levels appear to increase in relation to the stage of idiopathic AF progression.