Flurbiprofen-induced generalized bullous fixed drug eruption. (January 2014)

• Record Type: Journal Article
• Authors: Balta, I; Simsek, H; Simsek, GG
• Is Part Of: Human & experimental toxicology. Volume 33:Number 1(2014:Jan.)
• Page Start: 106
• Page End: 108
• Publication Date: 2014-01
• Subjects: Fixed drug eruption -- flurbiprofen -- generalized -- bullous; Toxicology -- Periodicals; 615.9
• DOI: 10.1177/0960327113489048
• Languages: English
• ISSNs: 0960-3271

Abstract

Fixed drug eruption (FDE) is an unusual drug-related side effect that results in recurrent lesions whenever the causative drugs are used. FDEs usually occur as a single, sharply demarcated, round erythematous patch or plaque, occasionally with localized bullae. The most common offending agents include antimicrobials, nonsteroidal anti-inflammatory drugs, and antiepileptics. There are some reports where contact dermatitis and cutaneous vasculitis have been associated with the use of flurbiprofen. We present the case of a 50-year-old man with flurbiprofen-induced generalized bullous FDE. To the best of our knowledge, the most serious form of FDE, the generalized bullous FDE, to be caused by flurbiprofen has not been reported previously.