Effect of atorvastatin on baroreflex sensitivity in subjects with type 2 diabetes and dyslipidaemia. (January 2014)

• Record Type: Journal Article
• Authors: Grigoropoulou, Pinelopi; Eleftheriadou, Ioanna; Zoupas, Christos; Makrilakis, Konstantinos; Papassotiriou, Ioannis; Margeli, Alexandra; Perrea, Despoina; Katsilambros, Nicholas; Tentolouris, Nicholas
• Is Part Of: Diabetes & vascular disease research. Volume 11:Number 1(2014:Jan.)
• Page Start: 26
• Page End: 33
• Publication Date: 2014-01
• Subjects: Atorvastatin -- diabetes -- baroreflex sensitivity -- autonomic function; Diabetic angiopathies -- Periodicals; 616.462005
• DOI: 10.1177/1479164113508293
• Languages: English
• ISSNs: 1479-1641

Abstract

In this prospective study, we examined the effect of atorvastatin treatment on baroreflex sensitivity (BRS) in subjects with type 2 diabetes. A total of 79 patients with type 2 diabetes with dyslipidaemia were recruited. A total of 46 subjects were enrolled to atorvastatin 10 mg daily and low-fat diet and 33 patients to low-fat diet only. BRS was assessed non-invasively using the sequence method at baseline, 3, 6 and 12 months. Treatment with atorvastatin increased BRS after 12 months (from 6.46 ± 2.79 ms/mmHg to 8.05 ± 4.28 ms/mmHg, p = 0.03), while no effect was seen with low-fat diet. Further sub-analysis according to obesity status showed that BRS increased significantly only in the non-obese group ( p = 0.036). A low dose of atorvastatin increased BRS in non-obese subjects with type 2 diabetes and dyslipidaemia after 1-year treatment. This finding emphasizes the beneficial effect of atorvastatin on cardiovascular system, beyond the lipid-lowering effects.