Advances in Statistical Approaches to Oncology Drug Development. (January 2014)

• Record Type: Journal Article
• Authors: Ivanova, Anastasia; Rosner, Gary L.; Marchenko, Olga; Parke, Tom; Perevozskaya, Inna; Wang, Yanping
• Is Part Of: Therapeutic innovation & regulatory science. Volume 48:Number 1(2014:Jan.)
• Page Start: 81
• Page End: 89
• Publication Date: 2014-01
• Subjects: cancer trial -- oncology drug development -- MTD -- model-based design -- stopping rule; Drugs -- Periodicals; Pharmacology -- Periodicals; Drugs -- Research -- Periodicals; Drugs -- Testing -- Periodicals; 615.1
• DOI: 10.1177/2168479013501309
• Languages: English
• ISSNs: 2168-4790

Abstract

The authors describe some recent developments in statistical methods and practice in oncology drug development from an academic and an industry perspective. Many adaptive designs were pioneered in oncology, and oncology is still at the forefront of novel methods to enable better and faster go/no-go decision making while controlling the cost.