Pyrazine based Pt(II) bis‐alkynyl organometallic complexes: Synthesis, characterization, and cytotoxic effect on A549 human lung carcinoma cells. (27th April 2017)

• Record Type: Journal Article
• Authors: Bhowmick, Sourav; Jana, Achintya; Marri, Subba R.; Gupta, Prerak; Behera, J.N.; Mandal, Biman B.; Das, Neeladri
• Is Part Of: Applied organometallic chemistry. Volume 31:Number 12(2017:Dec.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-04-27
• Subjects: A549 human lung carcinoma cells -- anticancer -- cytotoxic effect -- organometallic complex -- pyrazine -- X‐ray crystallography; Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.3824
• Languages: English
• ISSNs: 0268-2605

Abstract

Abstract : A facile and efficient synthesis of a series of five new pyrazine‐based organometallic complexes is being reported. The complexes (2 –6 ) have been fully characterized. Molecules2, 3 and6 were structurally characterized by single crystal X‐ray crystallographic analyses. Additionally, anticancer properties of these organometallic complexes have been studied against A549 human lung carcinoma cells. Biological studies suggest that complex5 (with pendant pyridine moieties) exhibited maximal growth inhibitory cytotoxic effect even at lower concentration (nearly 0.5–1 μM) whereas the other four compounds (2, 3, 4 and6 ) were non‐toxic below 1 μM concentration. Two complexes (4 and6) were effective only at higher doses (approx 30 μM) while the remaining two organometallic complexes (2 and3) were able to inhibit 50% cell growth at slightly lower concentration (nearly 10 μM). As far as IC50 is concerned, 5 exhibited a minimum value ranging between 3–5 μM which is comparable with cisplatin under similar conditions. Abstract : Five new pyrazine‐based organometallic complexes containing a pyrazine ring in the center and have two Pt(II)‐alkynyl branches protruding on either side have been synthesized. These pyrazine‐containing and π‐conjugated Pt(II)‐alkynyl complexes are quite rare. For the first time, these organometallic complexes have shown a potential application: cytotoxic potency against A549 human lung carcinoma cells