Increased trophoblast inclusions in placentas from prematurely born infants: A potential marker of risk for preterm neurodevelopmental outcomes. (December 2017)

• Record Type: Journal Article
• Authors: Firestein, Morgan R.; Abellar, Rosanna; Myers, Michael M.; Welch, Martha G.
• Is Part Of: Placenta. Volume 60(2017:Dec.)
• Page Start: 61
• Page End: 63
• Publication Date: 2017-12
• Subjects: Preterm birth -- Trophoblast inclusions -- Placenta -- Chorioamnionitis -- Neurodevelopmental risk; TI trophoblast inclusion -- GA gestational age; Placenta -- Periodicals; Reproduction -- Periodicals; Placenta -- Periodicals; Placenta -- Périodiques; Reproduction -- Périodiques; 612.63
• DOI: 10.1016/j.placenta.2017.10.006
• Languages: English
• ISSNs: 0143-4004

Abstract

Abstract: Trophoblast inclusions (TIs) are placental abnormalities of the trophoblast bilayer. Present in 2–8% of full-term placentas, they are associated with poor neurodevelopment, including autism. Although previously unstudied, examination of chorionic villi from 108 preterm births revealed a ∼4 fold increase in the frequency of TIs (30.5%). Frequency of TIs was inversely related to gestational age (GA); 43% of placentas <30 weeks and 20% of placentas ≥32 weeks had TIs (χ2 = 4.41, p = 0.036). This increased prevalence in preterm infants suggests that TIs may indicate adverse intrauterine processes or undetected genetic abnormalities and could identify infants at risk for poor neurodevelopment. Highlights: Trophoblast inclusions are associated with risk for autism. Trophoblast inclusions are increased in placentas of preterm infants. Trophoblast inclusions and preterm birth may share a causative factor.