Functionalized bispyridoneannelated BODIPY – Bright long-wavelength fluorophores. (March 2015)

• Record Type: Journal Article
• Authors: Zatsikha, Yuriy V.; Yakubovskyi, Viktor P.; Shandura, Mykola P.; Kovtun, Yuriy P.
• Is Part Of: Dyes and pigments. Volume 114(2015)
• Page Start: 215
• Page End: 221
• Publication Date: 2015-03
• Subjects: BODIPY -- Long-wavelength dyes -- Fluorophore -- Functionalization -- Pyridone -- Annelation; Dyes and dyeing -- Periodicals; Pigments -- Periodicals; 667.2
• DOI: 10.1016/j.dyepig.2014.11.016
• Languages: English
• ISSNs: 0143-7208

Abstract

Abstract: A simple approach to the modification of BODIPY nucleus has been developed. The method is based on the reaction of monofun≿tionalized acetaldehyde-substituted dye with primary amines or anilines followed by cyclization of enamine intermediates. This procedure allowed preparing a series of new stable intensive long-wavelength BODIPY derivatives ( λ em = 680–720 nm) with two functional substituents useful for various practical purposes, including bioconjugation and other biomedical applications. Graphical abstract: Highlights: The series of bispyridoneannelated BODIPY has been synthesized. A new method for bi-functionalization of BODIPY core has been developed. The long-wavelength intensive fluorophores ( λ em = 680–720 nm) have been synthesized.