Four new phenylpropanoid glycosides from Clausena dunniana var. robustaand their antiinflammatory activities. (December 2017)

• Record Type: Journal Article
• Authors: Guo, Yigong; Zhu, Shenglan; Wu, Guojing; Huang, Mengling; Yan, Shikai; Jin, Huizi; Zhang, Weidong
• Is Part Of: Phytochemistry letters. Volume 22(2017:Dec.)
• Page Start: 138
• Page End: 141
• Publication Date: 2017-12
• Subjects: Clausena dunniana var. robusta -- Clausenaglycosides -- Phenylpropanoid glycosides -- NF-&kappa -- B activation; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2017.09.020
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Four new compounds were isolated from the Clausena dunniana var. robusta . These new compounds were named as clausenaglycosides A– D. Fourteen known compounds were also isolated from this plant. Their absolute configurations were determined by NMR analyses and CD data. All isolated compounds were evaluated for their anti-inflammatory activities. Abstract: Four new phenylpropanoid glycosides, clausenaglycosides A–D (1–4 ), along with fourteen known compounds (5–18 ) were isolated from the leaves and twigs of Clausena dunniana var. robusta . The structures of the isolated compounds were determined by a combination of 1D and 2D NMR, MS, and CD spectroscopic data. The NF- κB inhibitory activity was evaluated in HeLa cells. Compound17 displayed a moderate inhibition against NF- κB activation.