Pro-apoptotic activity of acylated triterpenoid saponins from the stem bark of Albizia chevalieri harms. (December 2017)

• Record Type: Journal Article
• Authors: Noté, Olivier Placide; Messi, Lin Marcellin; Mbing, Joséphine Ngo; Azouaou, Sarah Ali; Sarr, Mamadou; Guillaume, Dominique; Muller, Christian Dominique; Pegnyemb, Dieudonné Emmanuel; Lobstein, Annelise
• Is Part Of: Phytochemistry letters. Volume 22(2017:Dec.)
• Page Start: 95
• Page End: 101
• Publication Date: 2017-12
• Subjects: Albizia chevalieri -- Mimosaceae -- Triterpenoid saponins -- Proapoptotic activity -- Pancreatic carcinoma AsPC-1; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2017.09.008
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Three new acylated glycosides of echinocystic acid, named chevalierosides A–C (1 –3 ) were isolated from the stem bark of Albizia chevalieri . Their structures were established on the basis of extensive analysis of 1D and 2D NMR experiments. Cytometric analyses showed that the isolated saponins induced apoptosis of two human cell lines (AsPC-1 and THP-1) in a dose-dependent manner. Abstract: As a continuation of our interest in apoptosis-inducing triterpenoid saponins from Albizia genus, phytochemical investigation of the stem bark of Albizia chevalieri led to the isolation of three new oleanane-type saponins, named chevalierosides A–C (1 –3 ). Their structures were established on the basis of extensive analysis of 1D and 2D NMR ( 1 H-, 13 C NMR, DEPT, COSY, TOCSY, ROESY, HSQC and HMBC) experiments, HRESIMS studies, and by chemical evidence. The pro-apoptotic effect of the three saponins was evaluated on two human cell lines (pancreatic carcinoma AsPC-1 and hematopoietic monocytic THP-1). Cytometric analyses showed that saponins1 –3 induced apoptosis of both human cell lines (AsPC-1 and THP-1) in a dose-dependent manner.