Three new napthalene derivatives from the endophytic fungus Phomopsis fukushii. (December 2017)

• Record Type: Journal Article
• Authors: Yang, Hai-Ying; Duan, Yan-Qing; Yang, Ye-Kun; Li, Jing; Liu, Xin; Ye, Lin; Mi, Qi-Li; Kong, Wei-Song; Zhou, Min; Yang, Guang-Yu; Li, Xue-Mei; Hu, Qiu-Fen
• Is Part Of: Phytochemistry letters. Volume 22(2017:Dec.)
• Page Start: 266
• Page End: 269
• Publication Date: 2017-12
• Subjects: Napthalene derivatives -- Phomopsis fukushii -- Diaporthaceae family -- Structure elucidation -- anti-MRSA activity; Botanical chemistry -- Periodicals; Chimie végétale -- Périodiques; 572.205
• DOI: 10.1016/j.phytol.2017.10.021
• Languages: English
• ISSNs: 1874-3900

Abstract

Graphical abstract: Highlights: Three new napthalene derivatives were isolated from the endophytic fungus Phomopsis fukushii. . Their structures were elucidated by spectroscopic methods. Compounds1 –3 exhibited good anti-MRSA activity. Abstract: An endophytic Phomopsis fukushii was isolated from the rhizome of Paris polyphylla var. yunnanensis, Diaporthaceae family, and three new (1–3 ) and four known napthalene derivatives (4 –7 ) were isolated from the fermentation products of this fungus. Their structures were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. Compounds1–3 were evaluated for their anti-methicillin-resistant Staphylococcus aureus (anti-MRSA) activity with vancomycin as positive control. The results showed that compounds1–3 showed good inhibitions with MCI valves of 4, 4 and 6 m g/mL, respectively.