Interictal cardiac autonomic nervous system disturbances in dogs with idiopathic epilepsy. (October 2017)

• Record Type: Journal Article
• Authors: Musteata, M.; Mocanu, D.; Stanciu, G.D.; Armasu, M.; Solcan, G.
• Is Part Of: Veterinary journal. Volume 228(2017)
• Page Start: 41
• Page End: 45
• Publication Date: 2017-10
• Subjects: Autonomic nervous system -- Canine epilepsy -- Heart rate variability; Veterinary medicine -- Periodicals; 636
• DOI: 10.1016/j.tvjl.2017.10.008
• Languages: English
• ISSNs: 1090-0233

Abstract

Highlights: Heart rate variability (HRV) is a useful tool in assessing autonomic nervous system (ANS). Dogs with idiopathic epilepsy elicit conductibility delays of the electric impulse considered as risk factors for developing severe arrhythmias. Dogs with idiopathic epilepsy exhibit parasympathetic hyperactivity in the interictal phase. Administration of antiepileptic drugs administration has no influence over the ANS pattern in dogs with idiopathic epilepsy. The ANS pattern in dogs with idiopathic epilepsy may have prognostic or therapeutic value. Abstract: Autonomic nervous system (ANS) activity in the interictal period (InIp) in dogs with presumed idiopathic epilepsy (pIE) was assessed using heart rate variability (HRV) analysis. The HRVs obtained from 28 pIE dogs with interictal epileptic discharges (InIEd; 11 with treatment and 17 without treatment) detected on electroencephalography (EEG) were compared with those obtained from 13 healthy dogs. On electrocardiographic (ECG) study, the P wave dispersion (PWD; P < 0.001), P max ( P = 0.004) and corrected QT interval (QTc; P = 0.025) were significantly increased in the pIE group. On the basis of HRV analysis, the pIE dogs had an increased activity of the parasympathetic component of the ANS, including the percentage of R-R interval (pNN50%) that differs more than 50 ms ( P = 0.011) and high frequency band (HF; P = 0.041). Administration of phenobarbitone had no influence on the ANS pattern when pIE subgroups were compared ( P > 0.05). In InIp, dogs elicited specific conductibility delays of the electrical impulses (increased PWD and QTc interval); these delays are considered to be risk factors for developing severe arrhythmias, such as atrial fibrillation and ventricular tachycardia. When compared with human beings, a different ANS pattern characterised by increased parasympathetic activity was observed, which may influence the therapeutic approach of IE in dogs.