Differential effects of lipid biosynthesis inhibitors on Zika and Semliki Forest viruses. (December 2017)

• Record Type: Journal Article
• Authors: Royle, Jamie; Donald, Claire L.; Merits, Andres; Kohl, Alain; Varjak, Margus
• Is Part Of: Veterinary journal. Volume 230(2017)
• Page Start: 62
• Page End: 64
• Publication Date: 2017-12
• Subjects: Zika virus -- Semliki Forest virus -- Lipid biosynthesis -- Antiviral agent; Veterinary medicine -- Periodicals; 636
• DOI: 10.1016/j.tvjl.2017.10.009
• Languages: English
• ISSNs: 1090-0233

Abstract

Abstract: The recent outbreak of infection with Zika virus (ZIKV; Flaviviridae ) has attracted attention to this previously neglected mosquito-borne pathogen and the need for efficient therapies. Since flavivirus replication is generally known to be dependent on fatty acid biosynthesis, two inhibitors of this pathway, 5-(tetradecyloxyl)-2-furoic acid (TOFA) and cerulenin, were tested for their potentiality to inhibit virus replication. At concentrations previously shown to inhibit the replication of other flaviviruses, neither drug had a significant antiviral affect against ZIKV, but reduced the replication of the non-related mosquito-borne Semliki Forest virus ( Togaviridae ).