Mean Platelet Volume and Related Factors in Patients at Different Stages of Diabetic Nephropathy: A Preliminary Study. (March 2014)

• Record Type: Journal Article
• Authors: Turgutalp, Kenan; Özhan, Onur; Akbay, Esen; Tombak, Anıl; Tiftik, Naci; Ozcan, Turkay; Yılmaz, Sercan; Helvacı, İlter; Kiykim, Ahmet
• Is Part Of: Clinical and applied thrombosis/hemostasis. Volume 20:Number 2(2014:Mar.)
• Page Start: 190
• Page End: 195
• Publication Date: 2014-03
• Subjects: mean platelet volume -- diabetes mellitus -- proteinuria -- diabetic nephropathy -- renal failure -- cardiovascular disease; Hemostasis -- Periodicals; Thrombosis -- Periodicals; 616.13
• DOI: 10.1177/1076029612456734
• Languages: English
• ISSNs: 1076-0296

Abstract

Introduction: Mean platelet volume (MPV) is an independent cardiovascular disease predictor, and characteristics of MPV in patients with diabetic nephropathy (DN) are not well known. Aim: To determine the MPV levels in patients at different stages of DN. Patients and Methods: The MPV levels were investigated in healthy participants (group 1, n = 157), patients with type 2 diabetes mellitus without complication (group 2, n = 160), diabetic patients with clinical proteinuria (group 3, n = 144), and in patients with chronic kidney disease due to DN (group 4, n = 160). Findings: The MPV level was higher in all diabetic patients than that in normal participants ( P < .05). The MPV values had a positive correlation with the serum creatinine and proteinuria, and a negative correlation with the glomerular filtration rate ([GFR] P < .001 for all, r values; .72, and .82, and −.92, respectively). Conclusion: The MPV values were higher in diabetic groups than that in normal participants. Both GFR and proteinuria were the most powerful determinants of MPV.